Frick Foundation for ALS Research
Frick Foundation for ALS Research
Professor Christine Vande Velde

Department of Medicine, Université de Montréal, Canada

Christine Vande Velde, B.Sc., Ph.D. (University of Manitoba) is an Assistant Professor in the Department of Medicine at the Université de Montréal since October 2007. Dr. Vande Velde is focussed on understanding the cell biological mechanisms underlying ALS pathogenesis. She uses a combination of cell culture and animal models to investigate two primary areas of interest: the impact of misfolded SOD1 on mitochondria and the role of TDP-43 in stress granules.

Dr. Vande Velde is a cell biologist with a focus on amyotrophic lateral sclerosis. She obtained her Ph.D. in Biochemistry from the University of Manitoba in 2001 for her work exploring BCL-2 proteins in mitochondrial-mediated mechanisms of programmed cell death. She then pursued postdoctoral studies at the University of California, San Diego in the laboratory of Dr. Don Cleveland (2001-2007) where she developed an expertise in working with SOD1 rodent models of ALS and was involved in the initial characterization of Alsin/ALS2. Her research has demonstrated that a portion of mutant SOD1 exists in a misfolded conformation which is preferentially associated with spinal cord mitochondria. This unique association may be an essential piece in understanding how motor neurons are selectively affected in ALS. In 2007, Dr. Vande Velde established her own laboratory at the CHUM Research center, an affiliate of the Université de Montréal, to further understand the impact of misfolded SOD1 on mitochondria in ALS.

Dr. Vande Velde has won a number of awards for her research including a Paralyzed Veterans’ of America fellowship, a Muscular Dystrophy Association Development grant, and she is currently a Research Scholar of the of FRSQ.

Dr. Eran Hornstein

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

Eran Hornstein, MD, PhD is affiliated with the Departments of Molecular Genetics at the Weizmann Institute of Science in Rehovot, Israel. He obtained his MD/PhD at The Hebrew University- Hadassah Medical School, Jerusalem, Israel. After Medical internship at the Hadassah Medical Center he moved to a postdoctoral training with Cliff Tabin at the Department of Genetics, Harvard Medical School. When he returned to Israel in 2006, he established a program that focuses on the study of microRNA genes in human disease. Dr. Hornstein is incumbent of the Helen and Milton Kimmelman Career Development Chair and the Dr. Sydney Brenner Chair. In recent years a major focus of his lab is the investigations of dysregulated miRNA in ALS.